Organic Contaminant Biodegradation by Oxidoreductase Enzymes in Wastewater Treatment.
Identifieur interne : 000047 ( Main/Exploration ); précédent : 000046; suivant : 000048Organic Contaminant Biodegradation by Oxidoreductase Enzymes in Wastewater Treatment.
Auteurs : Edward A. Barber [Royaume-Uni] ; Ziyi Liu [Royaume-Uni] ; Stephen R. Smith [Royaume-Uni]Source :
- Microorganisms [ 2076-2607 ] ; 2020.
Abstract
Organic contaminants (OCs), such as pharmaceuticals, personal care products, flame retardants, and plasticisers, are societally ubiquitous, environmentally hazardous, and structurally diverse chemical compounds whose recalcitrance to conventional wastewater treatment necessitates the development of more effective remedial alternatives. The engineered application of ligninolytic oxidoreductase fungal enzymes, principally white-rot laccase, lignin peroxidase, and manganese peroxidase, has been identified as a particularly promising approach for OC remediation due to their strong oxidative power, broad substrate specificity, low energy consumption, environmental benignity, and cultivability from lignocellulosic waste. By applying an understanding of the mechanisms by which substrate properties influence enzyme activity, a set of semi-quantitative physicochemical criteria (redox potential, hydrophobicity, steric bulk and pKa) was formulated, against which the oxidoreductase degradation susceptibility of twenty-five representative OCs was assessed. Ionisable, compact, and electron donating group (EDG) rich pharmaceuticals and antibiotics were judged the most susceptible, whilst hydrophilic, bulky, and electron withdrawing group (EWG) rich polyhalogenated compounds were judged the least susceptible. OC susceptibility scores were in general agreement with the removal rates reported for experimental oxidoreductase treatments (R2 = 0.60). Based on this fundamental knowledge, and recent developments in enzyme immobilisation techniques, microbiological enzymic treatment strategies are proposed to formulate a new generation of biological wastewater treatment processes for the biodegradation of environmentally challenging OC compounds.
DOI: 10.3390/microorganisms8010122
PubMed: 31963268
PubMed Central: PMC7022594
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Organic Contaminant Biodegradation by Oxidoreductase Enzymes in Wastewater Treatment.</title><author><name sortKey="Barber, Edward A" sort="Barber, Edward A" uniqKey="Barber E" first="Edward A" last="Barber">Edward A. Barber</name><affiliation wicri:level="1"><nlm:affiliation>Department of Civil and Environmental Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Civil and Environmental Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ</wicri:regionArea><wicri:noRegion>London SW7 2AZ</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Ziyi" sort="Liu, Ziyi" uniqKey="Liu Z" first="Ziyi" last="Liu">Ziyi Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Civil and Environmental Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Civil and Environmental Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ</wicri:regionArea><wicri:noRegion>London SW7 2AZ</wicri:noRegion></affiliation></author><author><name sortKey="Smith, Stephen R" sort="Smith, Stephen R" uniqKey="Smith S" first="Stephen R" last="Smith">Stephen R. Smith</name><affiliation wicri:level="1"><nlm:affiliation>Department of Civil and Environmental Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Civil and Environmental Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ</wicri:regionArea><wicri:noRegion>London SW7 2AZ</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:31963268</idno><idno type="pmid">31963268</idno><idno type="doi">10.3390/microorganisms8010122</idno><idno type="pmc">PMC7022594</idno><idno type="wicri:Area/Main/Corpus">000157</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000157</idno><idno type="wicri:Area/Main/Curation">000157</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000157</idno><idno type="wicri:Area/Main/Exploration">000157</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Organic Contaminant Biodegradation by Oxidoreductase Enzymes in Wastewater Treatment.</title><author><name sortKey="Barber, Edward A" sort="Barber, Edward A" uniqKey="Barber E" first="Edward A" last="Barber">Edward A. Barber</name><affiliation wicri:level="1"><nlm:affiliation>Department of Civil and Environmental Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Civil and Environmental Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ</wicri:regionArea><wicri:noRegion>London SW7 2AZ</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Ziyi" sort="Liu, Ziyi" uniqKey="Liu Z" first="Ziyi" last="Liu">Ziyi Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Civil and Environmental Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Civil and Environmental Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ</wicri:regionArea><wicri:noRegion>London SW7 2AZ</wicri:noRegion></affiliation></author><author><name sortKey="Smith, Stephen R" sort="Smith, Stephen R" uniqKey="Smith S" first="Stephen R" last="Smith">Stephen R. Smith</name><affiliation wicri:level="1"><nlm:affiliation>Department of Civil and Environmental Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Civil and Environmental Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ</wicri:regionArea><wicri:noRegion>London SW7 2AZ</wicri:noRegion></affiliation></author></analytic><series><title level="j">Microorganisms</title><idno type="ISSN">2076-2607</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Organic contaminants (OCs), such as pharmaceuticals, personal care products, flame retardants, and plasticisers, are societally ubiquitous, environmentally hazardous, and structurally diverse chemical compounds whose recalcitrance to conventional wastewater treatment necessitates the development of more effective remedial alternatives. The engineered application of ligninolytic oxidoreductase fungal enzymes, principally white-rot laccase, lignin peroxidase, and manganese peroxidase, has been identified as a particularly promising approach for OC remediation due to their strong oxidative power, broad substrate specificity, low energy consumption, environmental benignity, and cultivability from lignocellulosic waste. By applying an understanding of the mechanisms by which substrate properties influence enzyme activity, a set of semi-quantitative physicochemical criteria (redox potential, hydrophobicity, steric bulk and pKa) was formulated, against which the oxidoreductase degradation susceptibility of twenty-five representative OCs was assessed. Ionisable, compact, and electron donating group (EDG) rich pharmaceuticals and antibiotics were judged the most susceptible, whilst hydrophilic, bulky, and electron withdrawing group (EWG) rich polyhalogenated compounds were judged the least susceptible. OC susceptibility scores were in general agreement with the removal rates reported for experimental oxidoreductase treatments (R<sup>2</sup> = 0.60). Based on this fundamental knowledge, and recent developments in enzyme immobilisation techniques, microbiological enzymic treatment strategies are proposed to formulate a new generation of biological wastewater treatment processes for the biodegradation of environmentally challenging OC compounds.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">31963268</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Print">2076-2607</ISSN><JournalIssue CitedMedium="Print"><Volume>8</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>Jan</Month><Day>16</Day></PubDate></JournalIssue><Title>Microorganisms</Title><ISOAbbreviation>Microorganisms</ISOAbbreviation></Journal><ArticleTitle>Organic Contaminant Biodegradation by Oxidoreductase Enzymes in Wastewater Treatment.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E122</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/microorganisms8010122</ELocationID><Abstract><AbstractText>Organic contaminants (OCs), such as pharmaceuticals, personal care products, flame retardants, and plasticisers, are societally ubiquitous, environmentally hazardous, and structurally diverse chemical compounds whose recalcitrance to conventional wastewater treatment necessitates the development of more effective remedial alternatives. The engineered application of ligninolytic oxidoreductase fungal enzymes, principally white-rot laccase, lignin peroxidase, and manganese peroxidase, has been identified as a particularly promising approach for OC remediation due to their strong oxidative power, broad substrate specificity, low energy consumption, environmental benignity, and cultivability from lignocellulosic waste. By applying an understanding of the mechanisms by which substrate properties influence enzyme activity, a set of semi-quantitative physicochemical criteria (redox potential, hydrophobicity, steric bulk and pKa) was formulated, against which the oxidoreductase degradation susceptibility of twenty-five representative OCs was assessed. Ionisable, compact, and electron donating group (EDG) rich pharmaceuticals and antibiotics were judged the most susceptible, whilst hydrophilic, bulky, and electron withdrawing group (EWG) rich polyhalogenated compounds were judged the least susceptible. OC susceptibility scores were in general agreement with the removal rates reported for experimental oxidoreductase treatments (R<sup>2</sup> = 0.60). Based on this fundamental knowledge, and recent developments in enzyme immobilisation techniques, microbiological enzymic treatment strategies are proposed to formulate a new generation of biological wastewater treatment processes for the biodegradation of environmentally challenging OC compounds.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Barber</LastName><ForeName>Edward A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>Department of Civil and Environmental Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Ziyi</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Civil and Environmental Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Stephen R</ForeName><Initials>SR</Initials><AffiliationInfo><Affiliation>Department of Civil and Environmental Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>01</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Microorganisms</MedlineTA><NlmUniqueID>101625893</NlmUniqueID><ISSNLinking>2076-2607</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">enzymatic degradation</Keyword><Keyword MajorTopicYN="N">organic contaminant</Keyword><Keyword MajorTopicYN="N">oxidoreductase enzymes</Keyword><Keyword MajorTopicYN="N">redox potential</Keyword></KeywordList><CoiStatement>The authors declare no conflict of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>11</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>01</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>01</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>1</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>1</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>1</Month><Day>23</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31963268</ArticleId><ArticleId IdType="pii">microorganisms8010122</ArticleId><ArticleId IdType="doi">10.3390/microorganisms8010122</ArticleId><ArticleId 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Barber</name></noRegion><name sortKey="Liu, Ziyi" sort="Liu, Ziyi" uniqKey="Liu Z" first="Ziyi" last="Liu">Ziyi Liu</name><name sortKey="Smith, Stephen R" sort="Smith, Stephen R" uniqKey="Smith S" first="Stephen R" last="Smith">Stephen R. Smith</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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